OBJECTIVE: To review literature on amantadine therapy in patients with traumatic brain injury (TBI).

DATA SOURCES: MEDLINE (1966–March 2006), EMBASE (1974–March 2006), BIOSIS (1969–March 2006), and International Pharmaceutical Abstracts (1970–March 2006) were searched to identify papers on the clinical outcomes of patients with TBI treated with amantadine. A bibliographic search was also performed.

STUDY SELECTION AND DATA EXTRACTION: Papers were excluded if they were not published in English, if they included patients less than 16 years old, or if they included patients in whom the effects of multiple medications, rather than amantadine alone, were studied. Reports were categorized according to the time of initiation of amantadine following the injury.

DATA SYNTHESIS: Reports examining early initiation of amantadine suggest a possible benefit for treatment of decreased responsiveness and functional recovery. One report examining late initiation of amantadine failed to demonstrate benefit in the treatment of motor impairment, while 2 reports suggested possible improvement of functional recovery. Finally, reports examining late initiation of amantadine in the treatment of cognitive and behavioral therapy demonstrated possible benefit.

CONCLUSIONS: Further investigation is needed before either early or late initiation of amantadine can be recommended for treatment of decreased responsiveness and functional recovery. However, while additional research is conducted, late initiation of amantadine can be considered an option for the treatment of cognitive and behavioral impairments in patients with TBI.

J Pharm Technol 2007;23:95-103.

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